INFORM Africa (Role of Data Streams in Informing infection dynamics in Africa) is a 5-year project funded by the United States’ National Institutes of Health through its ‘Data Science for Health Recovery and Innovation in Africa’ (DS-I Africa) program.  The goal of INFORM Africa is to effectively use big data to address pressing public health needs related to SARS CoV-2 and HIV pandemics, with the aim of developing population-scale data streams as a cornerstone of future pandemic preparedness. The project will utilize existing data from Nigeria and South Africa, the two most impacted countries in Africa, accounting for 41% of the continent’s SARS-CoV-2 infection and about 40% of its HIV burden.