The goal of INFORM Africa is to effectively use big data to address pressing public health needs related to novel pandemic outbreaks such as SARS-CoV-2 and established pandemics such as HIV, with the aim of developing population-scale data streams as a cornerstone of future pandemic preparedness. The project utilizes data from Nigeria and South Africa, accounting for about 40% of people living with HIV on the continent, and epicenters for emerging pandemic impact and research to mitigate their effects.